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簡(jiǎn)要描述：類(lèi)器官Y-27632 dihydrochloride類(lèi)器官（Organoids）是指將成體干細(xì)胞或多能干細(xì)胞在體外三維培養(yǎng)形成的具有一定空間結(jié)構(gòu)的組織類(lèi)似物。類(lèi)器官在組織結(jié)構(gòu)、細(xì)胞類(lèi)型、自我更新能力和功能等方面與來(lái)源組織高度一致，從而在發(fā)育生物學(xué)、疾病造模、精準(zhǔn)醫(yī)學(xué)、藥物研發(fā)、基因和細(xì)胞療法、感染和免疫以及再生醫(yī)學(xué)等生物醫(yī)學(xué)的多個(gè)領(lǐng)域展現(xiàn)出*的優(yōu)勢(shì)。
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類(lèi)器官Y-27632 dihydrochloride
類(lèi)器官（Organoids）是指將成體干細(xì)胞或多能干細(xì)胞在體外三維培養(yǎng)形成的具有一定空間結(jié)構(gòu)的組織類(lèi)似物。類(lèi)器官在組織結(jié)構(gòu)、細(xì)胞類(lèi)型、自我更新能力和功能等方面與來(lái)源組織高度一致，從而在發(fā)育生物學(xué)、疾病造模、精準(zhǔn)醫(yī)學(xué)、藥物研發(fā)、基因和細(xì)胞療法、感染和免疫以及再生醫(yī)學(xué)等生物醫(yī)學(xué)的多個(gè)領(lǐng)域展現(xiàn)出*的優(yōu)勢(shì)。
產(chǎn)品介紹DESCRIPTION
| Background | Y-27632 dihydrochloride is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 dihydrochloride attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 dihydrochloride primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation[1][2][3][4][5]. |
技術(shù)參數(shù)
| M. W t | 320.26 | ||
| Formula | C14H23Cl2N3O | ||
| CAS No | 129830-38-2 | ||
| Storage | Powder | -20 °C | 3 years |
| In solvent | -80°C | 6 months | |
| -20 °C | 1 month | ||
| Solubility | DMSO | 33.33 mg/mL(104.07 mM; Need ultrasonic) | |
| H2O | 100 mg/mL(312.25 mM; Need ultrasonic) | ||
BIOLOGICAL ALTIVITY
In Vitro
Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively[1].
Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group[2].
In Vivo
Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group[3].
Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group)[4].
類(lèi)器官Y-27632 dihydrochloride
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