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類器官Prostaglandin E2
類器官（Organoids）是指將成體干細胞或多能干細胞在體外三維培養形成的具有一定空間結構的組織類似物。類器官在組織結構、細胞類型、自我更新能力和功能等方面與來源組織高度一致，從而在發育生物學、疾病造模、精準醫學、藥物研發、基因和細胞療法、感染和免疫以及再生醫學等生物醫學的多個領域展現出*的優勢。
產品介紹DESCRIPTION
| Background | Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. |
| Alias | PGE2；前列腺素 E2；地諾前列酮 |
技術參數
| M. W t | 352.47 | |
| Formula | C??H??O? | |
| CAS No | 363-24-6 | |
| Storage | Powder | -20°C 3 years |
| In solvent | -80°C 6 months | |
| -20°C 1 month | ||
| Solubility | DMSO | ≥ 100 mg/mL(283.71 mM) |
| Ethanol | 70 mg/mL(198.60 mM) | |
| H2O | < 0.1 mg/mL(insoluble) | |
BIOLOGICAL ALTIVITY
In Vitro
PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation[1].
In Vivo
PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats[2]. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction[3].
類器官Prostaglandin E2
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